Prof Niek de Wit
Senior Faculty
Niek de Wit is professor in Primary Care and head of department at the Julius Center of Health Sciences and Primary Care of the University Medical Center in Utrecht, the Netherlands (www.juliuscenter.nl). He is medical director of the Julius health centers, the academic primary care practice in Leidsche Rijn (www.lrjg.nl). His initial research focussed on the management of gastro-intestinal symptoms in primary care. In the past 10 years he has been working at the interface of clinical primary care practice and academic research, and initiated innovative programs on cardiovascular disease, elderly care, and cancer. His cancer research involves early diagnosis, shared decision making and follow-up care from general practice.
He actively participates in the guideline development program of the Dutch College of General Practice, and co-authored the Future strategy 2022 of the College. In 2012 he was appointed in the Quality of care Board of the Dutch Ministry of Health. He is one of the founding members of the European Society of Primary Care Gastroenterology, and served for 8 years in the scientific committee of the United European Gastroenterology. He is an active member of Ca-Pri, the primary care cancer research group, and in 2018 he joined CanTest as an international collaborator.
+31 88 7568165
Julius Center, University Medical Center Utrecht, the Netherlands
Diagnostic process of cancer in primary care
- CanTest Network Analysis
- Establishing which modalities of artificial intelligence machine learning (AI/ML) for early detection and diagnosis of cancer are ready for implementation in primary care in the NHS: a Systematic Review
- Artificial Intelligence for Detection Of Cancer
- Improving early detection of cancer in primary care (PhD)
- A review of clinical guidelines on the diagnosis of cancer in older adults
- Patterns of clinical features prior to diagnosis in patients with colorectal cancer: a retrospective cohort study
- Variation in timeliness of diagnostic investigations for symptomatic patients and effect on cancer outcomes: facilitating the implementation of Faster Diagnosis Standards
- Rubin G, Walter F, Emery J, and de Wit N. Reimagining the diagnostic pathway for gastro-intestinal cancer. Nature Reviews Gastroenterology and Hepatology, 2018; doi:10.1038/nrgastro.2018.1
- Renzi C, Kaushal A, Emery J, Hamilton W, Neal RD, Rachet B, Rubin G, Singh H, Walter FM, de Wit NJ, Lyratzopoulos G. Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms. Nature Reviews: Clinical Oncology, 2019, https://doi.org/10.1038/s41571-019-0249-6
- Jones OT, Calanzani N, Saji S, Duffy SW, Emery J, Hamilton W, Singh H, de Wit N, Walter F. Application of artificial intelligence to electronic health records for early detection and diagnosis of cancer in primary care: a Systematic Review. JMIR, 2020:23483, doi: 10.2196/preprints.23483
- van Erp NF, Helsper CW, Olyhoek SM, Janssen RRT, Winsveen A, Peeters PHM, de Wit NJ. Potential for reducing time to referral for colorectal cancer patients in primary care. Ann Fam Med, 2019, 17(5): 419-427, doi: 10.1370/afm.2446
- van Erp NF, Helsper CW, Slottje P, Brandenbarg D, Büchner FL, van Asselt KM,Muris J, Kortekaas MF, Peeters P, de Wit NJ. Time to diagnosis of symptomatic gastric and oesophageal cancer in the Netherlands: Where is the room for improvement? United European Gastroenterol J, 2020, 8(5): 607-620, doi: 10.1177/2050640620917804
- Forster AS, Rubin G, Emery J, Thompson M, Sutton S, de Wit N, Walter FM, Lyratzopoulos G. Measuring patient experience of diagnostic care and acceptability of testing. De Gruyter, 2021, doi: 10.1515/dx-2020-0112
- Jones OT, Calanzani N, Saji S, Duffy SW, Emery J, Hamilton W, Singh H, de Wit NJ, Walter FM. Artificial Intelligence Techniques That May Be Applied to Primary Care Data to Facilitate Earlier Diagnosis of Cancer: Systematic Review. J Med Internet Res, 2021;23(3):e23483. doi: 10.2196/23483
- Jones D, Di Martino E, Bradley SH, Essang B, Hemphill S, Wright JM, Renzi C, Surr C, Clegg A, De Wit N, Neal R. Factors affecting the decision to investigate older adults with potential cancer symptoms: a systematic review. British Journal of General Practice 2022; 72 (714): e1-e10. doi: 10.3399/BJGP.2021.0257
- de Groot E, Vermond D, Sills VA, Mol SSL, Walter FM, Rubin G, DE Wit NJ. Factors determining development of researchers within a research network on cancer diagnosis in primary care (CanTest): An interview study. BMJ Open 2022;12:e046321. doi: 10.1136/bmjopen-2020-046321
- Vermond D, de Groot E, Sills VA, Lyratzopoulos G, Walter FM, de Wit NJ, Rubin G. The evolution and co-evolution of a primary care cancer research network: From academic social connection to research collaboration. PLoS ONE 17(7): e0272255 2022. doi: 10.1371/journal.pone.0272255
- Benitez Majano S, Lyratzopoulos G, de Wit NJ, White B, Rachet B, Helsper C, Usher-Smith J, Renzi C. Mental Health Morbidities and Time to Cancer Diagnosis Among Adults With Colon Cancer in England. JAMA Network Open 2022; 5(10):e2238569. doi: 10.1001/jamanetworkopen.2022.38569
- Calanzani N, Pannebakker MM, Tagg MJ, Walford H, Holloway P, de Wit N, Hamilton W, Walter FM. Who are the patients being offered the faecal immunochemical test in routine English general practice, and for what symptoms? A prospective descriptive study. BMJ Open 2022; 12:e066051. doi: 10.1136/bmjopen-2022-066051
- Moullet M, Funston G, Mounce LTA, Abel GA, de Wit N, Walter FM, Zhou Y. Pre-diagnostic clinical features and blood tests in patients with colorectal cancer: a retrospective linked-data study. British Journal of General Practice June 2022; BJGP.2021.0563. doi: 10.3399/BJGP.2021.0563