Prof Yoryos Lyratzopoulos

Associate Director

Yoryos is a Professor of Cancer Healthcare Epidemiology and leads the Epidemiology of Cancer Healthcare and Outcomes (ECHO) group and the CanTest team within the University College London (UCL) Department of Behavioural Science and Health. He joined UCL in 2015, at the start of his Cancer Research UK Advanced Clinician Scientist Fellowship. He has a background in epidemiology, health services research, public health and internal medicine.

Empirical or conceptual work that Yoryos has led is cited in the current National Cancer Strategy for England 2015-2020 (Achieving World-Class Cancer Outcomes; the U.S. Institute of Medicine Report “Improving Diagnosis in Health Care”; and the narrative review of the WHO working party on the Global Burden of Diagnostic Errors in Primary Care (2016).

In 2016 Yoryos was awarded the Cancer Research UK Future Leader Prize, a prestigious award that recognises individuals who have demonstrated world-leading potential within their first ten post-doctoral years, being the first epidemiologist to be given the Prize.

You can view Yoryos’ profile on the UCL website here.

Follow Yoryos on Twitter @Glyratzopoulos

Institution

University College London, UK

Areas of Expertise

Cancer healthcare epidemiology; early diagnosis research; variation in measures/markers of early diagnosis; cancer patient experience surveys

Projects

Publications

Forster AS, Renzi C, Lyratzopoulos G. Diagnosing cancer in patients with ‘non-alarm’ symptoms: Learning from diagnostic care innovations in Denmark. Cancer Epidemiology, 2018; 54, 101-103
Stanciu MA, Law R-J, Nafees S, Hendry M, Yeo ST, Hiscock J, Lewis R, Edwards RT, Williams NH, Brain K, Brocklehurst P, Carson-Stevens A, Dolwani S, Emery J, Hamilton W, Hoare Z, Lyratzopoulos G, Rubin G, Smits S, Vedsted P, Walter FM, Wilkinson C, Neal RD. Development of an intervention to expedite cancer diagnosis through primary care: Protocol. BJGP Open 4 September 2018; bjgpopen18X101595
Herbert A, Lyratzopoulos G., Whelan J., Taylor R.M., Barber J., Gibson F., Fern L.A. Diagnostic timeliness in adolescents and young adults with cancer: a cross-sectional analysis of the BRIGHTLIGHT cohort. The Lancet Child and Adolescent Health, 2018; 2(3): 180-190
Lyratzopoulos G. Electronic patient records research to aid diagnostic reasoning for possible cancer in primary care. Br J Gen Pract 2018; 68 (674): 408-409
Salika T, Abel GA, Mendonca SC, von Wagner C, Renzi C, Herbert A, McPhail S, Lyratzopoulos G. Associations between diagnostic pathways and care experience in colorectal cancer: evidence from patient-reported data. Frontline Gastroenterology 2018;9:241-248
Renzi C, Lyratzopoulos G, Hamilton W, Rachet B. Opportunities for reducing emergency diagnoses of colon cancer in women and men: a data-linkage study on pre-diagnostic symptomatic presentations and benign diagnoses. Eur Journal Cancer Care. 2019. e13000. doi: 10.1111/ecc.13000
Herbert A, Abel GA, Winters S, McPhail S, Elliss-Brookes L, Lyratzopoulos G. Are inequalities in cancer diagnosis through emergency presentation narrowing, widening or remaining unchanged? Longitudinal analysis of English population-based data 2006-2013. J Epidemiol Community Health, 2019, 73(1): 3-10
Mendonca SC, Abel GA, Gildea C, McPhail S, Peake MD, Rubin G, Singh H, Hamilton W, Walter FM, Roland MO, Lyratzopoulos G. Associations between general practice characteristics with use of urgent referrals for suspected cancer and endoscopies: a cross-sectional ecological study. Family Practice, 2018, cmy118
Herbert A, Koo MM, Barclay ME, Greenberg DC, Abel GA, Levell NJ, Lyratzopoulos G. Stage-specific incidence trends of melanoma in an English region, 1996–2015: longitudinal analyses of population-based data. Melanoma Research, 2018. doi: 10.1097/CMR.0000000000000489
Maringe C, Rachet B, Lyratzopoulos G, Rubio FJ. Persistent inequalities in unplanned hospitalisation among colon cancer patients across critical phases of their care pathway, England, 2011–13. British Journal of Cancer, 2018, 119:5, 551-557
Zhou Y, Funston G, Lyratzopoulos G, Walter FM. Improving the Timely Detection of Bladder and Kidney Cancer in Primary Care. Advances in Therapy, 2019, https://doi.org/10.1007/s12325-019-00966-x
Watson J, Salisbury C, Banks J, Whiting P, Hamilton W. Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records. British Journal of Cancer, 2019, 120:1045-1051
Renzi C, Kaushal A, Emery J, Hamilton W, Neal RD, Rachet B, Rubin G, Singh H, Walter FM, de Wit NJ, Lyratzopoulos G. Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms. Nature Reviews: Clinical Oncology, 2019, https://doi.org/10.1038/s41571-019-0249-6
Pearson C, Fraser J, Peake M, Valori R, Poirier V, Coupland VH, Hiom S, McPhail S, Moffat J, Lyratzopoulos G, Shelton J. Establishing population-based surveillance of diagnostic timeliness using linked cancer registry and administrative data for patients with colorectal and lung cancer. Cancer Epidemiology, 2019, 61:111-118
Herbert A, Abel GA, Winters S, McPhail S, Elliss-Brookes L, Lyratzopoulos G. Cancer diagnoses after emergency GP referral or A&E attendance in England: Determinants and time trends in Routes to Diagnosis data, 2006–2015. BJGP, 2019, bjgp19X705473
Koo MM, Rubin G, McPhail S, Lyratzopoulos G. Incidentally diagnosed cancer: population-based evidence on frequency, variation, and commonly preceding clinical scenarios. BMJ Open, 2019, 9:e028362
Zhou Y, van Melle M, Singh H, Hamilton W, Lyratzopoulos G, Walter FM. Quality of the Diagnostic Process in Patients Presenting with Symptoms Suggestive of Bladder or Kidney Cancer: A Systematic Review. British Medical Journal Open, 2019, 2019;9:e029143. doi: 10.1136/bmjopen-2019-029143
Herbert A, Winters S, McPhail S, Elliss-Brookes L, Lyratzopoulos G, Abel G. Population trends in emergency cancer diagnoses: The role of changing patient case-mix. Cancer Epidemiology, 63, doi: 10.1016/j.canep.2019.101574
Koo MM, Swann R, McPhail S, Abel GA, Elliss-Brookes L, Rubin GP, Lyratzopoulos G. Presenting symptoms of cancer and stage at diagnosis: evidence from a cross-sectional, population-based study. The Lancet Oncology, 2019, doi: 10.1016/S1470-2045(19)30595-9
Swann R, Lyratzopoulos G, Rubin G, Pickworth E, McPhail S. The frequency, nature and impact of GP-assessed avoidable delays in a population-based cohort of cancer patients. Cancer Epidemiology, 2019, doi: 10.1016/j.canep.2019.101617
Rafiq M, Hayward A, Warren-Gash C, Denaxas S, Gonzalez-Izquierdo A, Lyratzopoulos G, Thomas S. Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study. Journal of Allergy and Clinical Immunology, 2019, doi: 10.1016/j.jaci.2019.10.033
Zhou Y, Abel GA, Hamilton W, Singh H, Walter FM, Lyratzopoulos G. Imaging activity possibly signalling missed diagnostic opportunities in bladder and kidney cancer: A longitudinal data-linkage study using primary care electronic health records. Cancer Epidemiology, 2020, doi: 10.1016/j.canep.2020.101703
Lyratzopoulos G, Abel GA. Assessing patients at risk of symptomatic-but-as-yet-undiagnosed cancer in primary care using information from patient records. Br J Cancer. 2020, Jun;122(12):1729-1731.. doi: 10.1038/s41416-020-0828-4
Kaushal A, Waller J, von Wagner C, Kummer S, Whitaker K, Puri A, Lyratzopoulos G, Renzi C. The role of chronic conditions in influencing symptom attribution and anticipated help-seeking for potential lung cancer symptoms: a vignette-based study. BJGP Open, 2020, doi: 10.3399/bjgpopen20X101086
Bright CJ, Gildea C, Lai J, Elliss-Brookes L, Lyratzopoulos G. Does geodemographic segmentation explain differences in route of cancer diagnosis above and beyond person-level sociodemographic variables? Journal of Public Health, 2020, fdaa111, doi: 10.1093/pubmed/fdaa111
Sud A, Torr B, Jones ME, Broggio J, Scott S, Loveday C, Garrett A, Gronthoud F, Nicol DL, Jhanji S, Boyce SA, Williams M, Riboli E, Muller DC, Kipps E, Larkin J, Navani N, Swanton C, Lyratzopoulos G, McFerran E, Lawler M, Houlston R, Turnbull C. Effect of delays in the 2-week-wait cancer referral pathway during the COVID-19 pandemic on cancer survival in the UK: a modelling study. The Lancet Oncology, 2020, 21(8): 1035-1044, doi: 10.1016/S1470-2045(20)30392-2
Sud A, Jones ME, Broggio J, Loveday C, Torr B, Garrett A, Nicol DL, Jhanji S, Boyce SA, Gronthoud F, Ward P, Handy JM, Yousaf N, Larkin J, Suh Y-E, Scott S, Pharoah PDP, Swanton C, Abbosh C, Williams M, Lyratzopoulos G, Houlston R, Turnbull C. Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic. Annals of Oncology, 2020, 31(8): 1065-1074, doi: 10.1016/j.annonc.2020.05.009
Sud A, Jones M, Broggio J, Scott S, Loveday C, Torr B, Garrett A, Nicol DL, Jhanji S, Boyce SA, Williams M, Lyratzopoulos G, Barry C, Riboli E, Kipps E, McFerran E, Lawler M, Muller DC, Abulafi M, Houlston R, Turnbull CA. Quantifying and mitigating the impact of the COVID-19 pandemic on outcomes in colorectal cancer. Gut, 2020, doi: 10.1101/2020.04.28.20083170
Price S, Spencer A, Zhang X, Ball S, Lyratzopoulos, Mujica-Mota R, Stapley S, Ukoumunne OC, Hamilton W. Trends in time to cancer diagnosis around the period of changing national guidance on referral of symptomatic patients: A serial cross-sectional study using UK electronic healthcare records from 2006–17. Cancer Epidemiology, 2020; 101805, doi: 10.1016/j.canep.2020.101805
Koo MM, Lyratzopoulos G, Herbert A, Abel GA, Taylor RM, Barber JA, Gibson F, Whelan J, Fern LA. Association of Self-reported Presenting Symptoms With Timeliness of Help-Seeking Among Adolescents and Young Adults With Cancer in the BRIGHTLIGHT Study. JAMA Netw Open. 2020 Sep 1;3(9):e2015437. doi: 10.1001/jamanetworkopen.2020.15437
Loveday C, Sud A, Jones ME, Broggio J, Scott S, Gronthound F, Torr B, Garrett A, Nicol DL, Jhanji S, Boyce SA, Williams M, Barry C, Riboli E, Kipps E, McFerran E, Muller DC, Lyratzopoulos G, Lawler M, Abulafi M, Houlston RS, Turnbull C. Prioritisation by FIT to mitigate the impact of delays in the 2-week wait colorectal cancer referral pathway during the COVID-19 pandemic: a UK modelling study. Gut, 2020, gutjnl-2020-321650. doi: 10.1136/gutjnl-2020
Renzi C, Lyratzopoulos G. Comorbidity and the diagnosis of symptomatic-but-as-yet-undiagnosed cancer. Br J Gen Pract. 2020;70(698):e598-e599
Koo MM, Swann R, McPhail S, Abel GA, Renzi C, Rubin GP, Lyratzopoulos G. The prevalence of chronic conditions in patients diagnosed with one of 29 common and rarer cancers: A cross-sectional study using primary care data. Cancer Epidemiology, 2020, 69: 101845, doi: 10.1016/j.canep.2020.101845
Zhou Y, Walter FM, Singh H, Hamilton W, Abel GA, Lyratzopoulos. Prolonged Diagnostic Intervals as Marker of Missed Diagnostic Opportunities in Bladder and Kidney Cancer Patients with Alarm Features: A Longitudinal Linked Data Study. Cancers, 2021, 13(1): 156, doi: 10.3390/cancers13010156
Koo MM, Unger-Saldana K, Mwaka AD, Corbex M, Ginsburg O, Walter FM, Calanzani N, Moodley J, Rubin GP, Lyratzopoulos G. Conceptual Framework to Guide Early Diagnosis Programs for Symptomatic Cancer as Part of Global Cancer Control. JCO Global Oncology, 2021 Jan: 7:35-45, doi: 10.1200/GO.20.00310
Herbert A, Barclay ME, Koo MM, Rous B, Greenberg DC, Abel G, Lyratzopoulos G. Stage–specific incidence trends of renal cancers in the East of England, 1999–2016. Cancer Epidemiology, 2021, 71(A), doi: 10.1016/j.canep.2020.101883
Forster AS, Rubin G, Emery J, Thompson M, Sutton S, de Wit N, Walter FM, Lyratzopoulos G. Measuring patient experience of diagnostic care and acceptability of testing. De Gruyter, 2021, doi: 10.1515/dx-2020-0112
Barclay ME, Abel GA, Greenberg DC, Rous B, Lyratzopoulos G. The Socio-demographic variation in stage at diagnosis of breast, bladder, colon, endometrial, lung, melanoma, prostate, rectal, renal and ovarian cancer in England and its population impact. British Journal of Cancer, 2021, doi: 10.1038/s41416-021-01279-z
Danckert B, Zalounina Falborg A, Christensen NL, Frederiksen H, Lyratzopoulos G, McPhail S, Ryg J, Vedsted P, Thomsen LA, Jensen H. Routes to diagnosis and the association with the prognosis in patients with cancer – A nationwide register-based cohort study in Denmark. Cancer Epidemiology, 2021. doi:10.1016/j.canep.2021.101983
White B, Rafiq M, Gonzalez-Izquierdo A, Hamilton W, Price S, Lyratzopoulos G. Risk of cancer following primary care presentation with fatigue: A population-based cohort study of a quarter of a million patients. Br J Cancer (2022). doi: 10.1038/s41416-022-01733- 6
Koo MM, Swann R, McPhail S, Abel GA, Renzi C, Rubin GP, Lyratzopoulos G. Morbidity and measures of the diagnostic process in primary care for patients subsequently diagnosed with cancer. Family Practice. 2021 Nov 30. doi: 10.1093/fampra/cmab139
Forster AS, Herbert A, Koo MM, Taylor RM, Gibson F, Whelan JF, Lyratzopoulos G, Fern LA. Associations between diagnostic time intervals and health-related quality of life, clinical anxiety and depression in adolescents and young adults with cancer: cross-sectional analysis of the BRIGHTLIGHT cohort. Br J Cancer (2022). doi: 10.1038/s41416-022-01698-6
Erridge S, Lyratzopoulos G, Renzi C, Millar A, Lee R. Rapid Diagnostic Centres and early cancer diagnosis. British Journal of General Practice 2021; 71 (712): 487-488. doi: 10.3399/bjgp21X717413
Zhou Y, Walter FM, Mounce L, Abel GA, Singh H, Hamilton W, Stewart GD, Lyratzopoulos G. Identifying opportunities for timely diagnosis of bladder and renal cancer via abnormal blood tests: a longitudinal linked data study. British Journal of General Practice. Dec 2021; doi: 10.3399/BJGP.2021.0282
White B, Renzi C, Rafiq M, Abel GA, Jensen H, Lyratzopoulos G. Does changing healthcare use signal opportunities for earlier detection of cancer? A review of studies using information from electronic patient records. Cancer Epidemiology, 2021, 102072, ISSN 1877-7821, doi: 10.1016/j.canep.2021.102072.
Wiering B, Lyratzopoulos G, Hamilton W, Campbell J, Abel G. Concordance with urgent referral guidelines in patients presenting with any of six ‘alarm’ features of possible cancer: a retrospective cohort study using linked primary care records. BMJ Quality & Safety. 04 October 2021. doi: 10.1136/bmjqs-2021-013425
Martins T, Abel G, Ukoumunne OC, Mounce LTA, Price S, Lyratzopoulos G, Chinegwundoh F, Hamilton W. Ethnic inequalities in routes to diagnosis of cancer: A population-based UK cohort study. Br J Cancer (2022). doi: 10.1038/s41416-022-01847-x
Vermond D, de Groot E, Sills VA, Lyratzopoulos G, Walter FM, de Wit NJ, Rubin G. The evolution and co-evolution of a primary care cancer research network: From academic social connection to research collaboration. PLoS ONE 17(7): e0272255 2022. doi: 10.1371/journal.pone.0272255
Rafiq M, Abel G, Renzi C, Lyratzopoulos G. Inflammatory marker testing in primary care in the year before Hodgkin lymphoma diagnosis: a UK population-based case–control study in patients aged ≤50 years. British Journal of General Practice; 72 (721): e546-e555. doi: 10.3399/BJGP.2021.0617
White B, Rafiq M, Gonzalez-Izquierdo A, Hamilton W, Price S, Lyratzopoulos G. Risk of cancer following primary care presentation with fatigue: A population-based cohort study of a quarter of a million patients. Br J Cancer (2022). doi: 10.1038/s41416-022-01733- 6
Benitez Majano S, Lyratzopoulos G, de Wit NJ, White B, Rachet B, Helsper C, Usher-Smith J, Renzi C. Mental Health Morbidities and Time to Cancer Diagnosis Among Adults With Colon Cancer in England. JAMA Network Open 2022; 5(10):e2238569. doi: 10.1001/jamanetworkopen.2022.38569
White B, Renzi C, Barclay M, Lyratzopoulos G. Underlying cancer risk among patients with fatigue and other vague symptoms in primary care: a population-based cohort study. British Journal of General Practice 31 Oc 2022. doi: 10.3399/BJGP.2022.0371
Martins T, Abel G, Ukoumunne OC, Price S, Lyratzopoulos G, Chinegwundoh F, Hamilton W. Assessing Ethnic Inequalities in Diagnostic Interval of Common Cancers: A Population-Based UK Cohort Study. Cancers 2022; 14(13):3085. doi: 10.3390/cancers14133085
Nicholson BD, Lyratzopoulos G. Progress and priorities in reducing the time to cancer diagnosis. Br J Cancer 2022. doi: 10.1038/s41416-022-02045-5
Danckert B, Christensen NL, Falborg AZ, Frederiksen H, Lyratzopoulos G, McPhail S, Pedersen AF, Ryg J, Thomsen LA, Vedsted P, Jensen H. Assessing how routes to diagnosis vary by the age of patients with cancer: a nationwide register-based cohort study in Denmark. BMC Cancer 22, 906 2022. doi: 10.1186/s12885-022-09937-y
Rafiq M, Abel G, Renzi C, Lyratzopoulos G. Steroid prescribing in primary care increases prior to Hodgkin lymphoma diagnosis: A UK nationwide case-control study. Cancer Epidemiology 2022, Vol 81, 102284. doi: 10.1016/j.canep.2022.102284